Protein name:
Mitogen-activated protein kinase kinase kinase 7 ;
Alternative:
Transforming growth factor-beta-activated kinase 1 (TGF-beta-activated kinase 1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Identified in the TRIKA2 complex composed of MAP3K7, TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its repressed activity. Interacts with TRAF6 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with TAOK1 and TAOK2; interaction with TAOK2 interferes with MAP3K7 interaction with IKKA, thus preventing NF-kappa-B activation. Interacts with WDR34 (via WD domains). Interacts with RBCK1. Interacts with CYLD. Interacts with TGFBR1; induces MAP3K7 activation by TRAF6. Interacts with MAPK8IP1 (By similarity). Interacts with isoform 1 of VRK2.
Function:
Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
Subcellular Location:
N/A
Protein Attributes:
50:
MSTASAASSS | SSSSAGEMIE | APSQVLNFEE | IDYKEIEVEE | VVGRGAFGVV |
100:
CKAKWRAKDV | AIKQIESESE | RKAFIVELRQ | LSRVNHPNIV | KLYGACLNPV |
150:
CLVMEYAEGG | SLYNVLHGAE | PLPYYTAAHA | MSWCLQCSQG | VAYLHSMQPK |
200:
ALIHRDLKPP | NLLLVAGGTV | LKICDFGTAC | DIQTHMTNNK | GSAAWMAPEV |
250:
FEGSNYSEKC | DVFSWGIILW | EVITRRKPFD | EIGGPAFRIM | WAVHNGTRPP |
300:
LIKNLPKPIE | SLMTRCWSKD | PSQRPSMEEI | VKIMTHLMRY | FPGADEPLQY |
350:
PCQYSDEGQS | NSATSTGSFM | DIASTNTSNK | SDTNMEQVPA | TNDTIKRLES |
400:
KLLKNQAKQQ | SESGRLSLGA | SRGSSVESLP | PTSEGKRMSA | DMSEIEARIA |
450:
ATTAYSKPKR | GHRKTASFGN | ILDVPEIVIS | GNGQPRRRSI | QDLTVTGTEP |
500:
GQVSSRSSSP | SVRMITTSGP | TSEKPTRSHP | WTPDDSTDTN | GSDNSIPMAY |
550:
LTLDHQLQPL | APCPNSKESM | AVFEQHCKMA | QEYMKVQTEI | ALLLQRKQEL |
600:
VAELDQDEKD | QQNTSRLVQE | HKKLLDENKS | LSTYYQQCKK | QLEVIRSQQQ |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Human
Mouse
ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 7
ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 7
ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 7
ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 7
Protein for Human Mitogen-activated protein kinase kinase kinase 7
Protein for Human Mitogen-activated protein kinase kinase kinase 7
Protein for Human Mitogen-activated protein kinase kinase kinase 7
Protein for Human Mitogen-activated protein kinase kinase kinase 7
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B AND 1C)
tissue :
Lung .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1D);TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A)
tissue :
Trachea .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A)
tissue :
Uterus .
8.
"A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3."
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Kuroyanagi N.
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Yamaguchi K.
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J. Biol. Chem.271:13675-13679(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF MAP2K3/MKK3 AND MAP2K6/MKK6
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TAB1/MAP3K7IP1
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION;FUNCTION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TRAF6 AND TAB1/MAP3K7IP1;FUNCTION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TAB1;PHOSPHORYLATION AT THR-184; THR-187 AND SER-192;ACTIVATION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-192;ENZYME REGULATION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEPHOSPHORYLATION BY PPM1B/PP2CB;INTERACTION WITH PPM1B/PP2CB
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION;FUNCTION;ENZYME REGULATION;INTERACTION WITH TAB1/MAP3K7IP2 AND TAB2/MAP3K7IP2;IDENTIFICATION IN THE TRIKA2 COMPLEX
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH IRAK; TAB1/MAP3K7IP1; TAB2/MAP3K7IP2 AND TRAF6;PHOSPHORYLATION;ENZYME REGULATION;SUBCELLULAR LOCATION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PELI1 AND PELI2
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PELI3
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH SMAD7; MAP2K3 AND P38 KINASE;MUTAGENESIS OF LYS-63
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TAB3/MAP3K7IP3
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DAB2
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
23.
"The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway."
Thiefes A.
,
Wolf A.
,
Doerrie A.
,
Grassl G.A.
,
Matsumoto K.
,
Autenrieth I.
,
Bohn E.
,
Sakurai H.
,
Niedenthal R.
,
Resch K.
,
Kracht M.
EMBO Rep.7:838-844(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION;PHOSPHORYLATION AT THR-187 BY AUTOCATALYSIS;SUBUNIT;FUNCTION
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;ENZYME REGULATION;INTERACTION WITH TAOK1 AND TAOK2
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PP2A AND PPP6C;DEPHOSPHORYLATION AT THR-187 BY PP2A AND PPP6C
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RBCK1
27.
"Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses."
Reiley W.W.
,
Jin W.
,
Lee A.J.
,
Wright A.
,
Wu X.
,
Tewalt E.F.
,
Leonard T.O.
,
Norbury C.C.
,
Fitzpatrick L.
,
Zhang M.
,
Sun S.C.
J. Exp. Med.204:1475-1485(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION;INTERACTION WITH CYLD;DEUBIQUITINATION BY CYLD
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Platelet .
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TGFBR1
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH VRK2
32.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389 AND SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
34.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH WDR34
35.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389 AND SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
36.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TAB2;PHOSPHORYLATION AT THR-187
37.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON ENZYME REGULATION
38.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389 AND SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
39.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION
40.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
41.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
42.
"TRIM5 is an innate immune sensor for the retrovirus capsid lattice."
Pertel T.
,
Hausmann S.
,
Morger D.
,
Zueger S.
,
Guerra J.
,
Lascano J.
,
Reinhard C.
,
Santoni F.A.
,
Uchil P.D.
,
Chatel L.
,
Bisiaux A.
,
Albert M.L.
,
Strambio-De-Castillia C.
,
Mothes W.
,
Pizzato M.
,
Gruetter M.G.
,
Luban J.
Nature472:361-365(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH TRIM5;PHOSPHORYLATION AT THR-187
43.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389 AND SER-439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
44.
"Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFalpha-induced NF-kappaB activation via mediating TAK1 degradation."
Fan Y.
,
Shi Y.
,
Liu S.
,
Mao R.
,
An L.
,
Zhao Y.
,
Zhang H.
,
Zhang F.
,
Xu G.
,
Qin J.
,
Yang J.
Cell. Signal.24:1381-1389(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION AT LYS-72
45.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 31-328 IN COMPLEX WITH TAB1 AND ADENOSINE